For I know the plans I have for you, declares the LORD, plans to prosper you and not to harm you, plans to give you hope and a future.Those were the words of God to the exiles. People who felt abandoned and displaced, by and large by no fault of their own. I believe the Lord wanted to encourage those people by promising them a future. He also had plans "not to harm you" which was something perhaps that they were unsure of because of their life experience to date. He wants to give us hope (which is given through Jesus) and a future. I see people with disabilities in this verse. It seems a word of reassurance to those who might not be entirely sure of what God is up to on the basis of their experience.
As is typical, in His kindness God knows of our wavering trust and gives us a shot of confidence and hope. How could one be more encouraging than to say, "you have a future" and "I have plans for you" and "I have plans to prosper you."
This verse has been an encouragement to me and I don't face the issues of disability, personally, that many face. I hope those who are feeling overwhelmed by their disability or the discriminatory effects of their disability will find a "hope and a future" in this passage.